Evidence
What the research shows
In murine studies, SLU-PP-332 demonstrated enhanced potency at ERRα compared to earlier compounds, leading to significant improvements in endurance capacity. Research indicates that this pan-agonist activates gene programs associated with acute endurance exercise in skeletal muscle, providing insights into the transcriptional networks that govern oxidative metabolism. These findings position SLU-PP-332 as a valuable tool for exploring metabolic adaptability in vivo, with implications for understanding energy metabolism.